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486460-32-6
Anti-Diabetic
C16H15F6N5O
407.31 g/mol
Amorphous
Commercial
Ready
Ready
Sitagliptin is an anti-diabetic drug, falling under the class of blood glucose lowering drugs. It is used to lower blood sugar levels in adults with type 2 diabetes mellitus, by increasing levels of natural substances called incretins, which help to control blood sugar by increasing insulin release. Over time, Sitagliptin may also decrease your chances of heart attack, stroke, or other diabetes-related complications such as kidney failure, nerve damage, eye problems, or gum disease. This drug can be used as monotherapy or in combination with other glucose lowering medicines. Sitagliptin is administered through oral route by way of film-coated tablets.
Sitagliptin is a competitive, reversible dipeptidyl peptidase 4 (DPP-4) inhibitor. Inhibition of this enzyme slows the breakdown of Glucagon-like peptide-1 (GLP-1) and Glucose-dependent insulinotropic polypeptide (GIP). GLP-1 and GIP stimulate the release of insulin from beta cells in the pancreas while inhibiting release of glucagon from pancreatic beta cells. These effects together reduce the breakdown of glycogen in the liver and increase insulin release in response to glucose. Thus, Sitagliptin binds to DPP-4 in a reversible manner which increases the concentrations of incretin hormones.
Ornet Pharmaceuticals, based out of Gujarat, India, is a leading manufacturer and global supplier of Sitagliptin API. Driven by technically sound, research-oriented leaders, each with over 2 decades of hands-on experience, Ornet develops and manufactures a wide array of complex APIs catering to multiple categories in its product portfolio, such as anti-diabetics, blood related, hormones, etc. Ornet’s Sitagliptin API is the result of the “Quality over Quantity” approach taken by the organization for all R&D and manufacturing practices. This approach, along with the strategically located manufacturing facility in Gujarat, allows for Ornet to be a primary source, both domestically and globally, for all API needs.
Products protected by valid patents are not offered for commercial sale in countries where the sale of such products constitutes patent infringement but are offered solely for uses reasonably related to the development and submission of information under a law regulating the manufacture, use or sale of drugs. It is within the buyer’s responsibility and liability to check the patent situation of the product in the imported market(s).
