Dapagliflozin

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CAS

461432-26-8

Treatment Category

Anti-Diabetic

Molecular Formula

C21H25ClO6

Molecular Weight

408.9 g/mol

Nature

Amorphous

Status

Commercial

EU DMF Readiness

Ready

US DMF Readiness

Ready

Ornet Dapagliflozin Characteristics

  • Pure, stable, amorphous nature
  • Excellent control of impurity profile
  • Particle Size Distribution as per the needs of the Finished Drug Formulator

Drug Description:

Dapagliflozin is an anti-diabetic drug, falling under the class of blood glucose lowering drugs. It is used to lower blood sugar levels and reduce the risk of cardiovascular disease and failure in adults with type 2 diabetes mellitus. Dapagliflozin is also prescribed to reduce the risk of end-stage kidney disease leading to hospitalization or death from heart problems in adults who also have kidney problems caused by type 2 diabetes. The drug can be used as monotherapy or in combination with other glucose lowering medicines. Dapagliflozin is administered through oral route by way of coated and film-coated tablets, as well as intravenous administration.

Mechanism of Action:

Dapagliflozin is a sodium-glucose co-transporter-2 (SGLT2) inhibitor used for the treatment of type 2 diabetes. SGLT2 is the main transporter that mediates reabsorption of glucose in the kidneys, from the glomerular filtrate back into the circulation. By inhibiting SGLT2, Dapagliflozin blocks reabsorption of filtered glucose in the kidney, increasing urinary glucose excretion and reducing blood glucose levels.

API Expertise:

Ornet Pharmaceuticals, based out of Gujarat, India, is a leading manufacturer and global supplier of Dapagliflozin API. Driven by technically sound, research-oriented leaders, each with over 2 decades of hands-on experience, Ornet develops and manufactures a wide array of complex APIs catering to multiple categories in its product portfolio, such as anti-diabetics, blood related, hormones, etc. Ornet’s Dapagliflozin API is the result of the “Quality over Quantity” approach taken by the organization for all R&D and manufacturing practices. This approach, along with the strategically located manufacturing facility in Gujarat, allows for Ornet to be a primary source, both domestically and globally, for all API needs.

DISCLAIMER:

Products protected by valid patents are not offered for commercial sale in countries where the sale of such products constitutes patent infringement but are offered solely for uses reasonably related to the development and submission of information under a law regulating the manufacture, use or sale of drugs. It is within the buyer’s responsibility and liability to check the patent situation of the product in the imported market(s).